Sphingolipid diversity in Candida auris: unraveling interclade and drug resistance fingerprints.

ABSTRACT: In this study, we explored the sphingolipid (SL) landscape in Candida auris, which plays pivotal roles in fungal biology and drug susceptibility. The composition of SLs exhibited substantial variations at both the SL class and molecular species levels among clade isolates. Utilizing principal component analysis, we successfully differentiated the five clades based on their SL class composition. While phytoceramide (PCer) was uniformly the most abundant SL class in all the isolates, other classes showed significant variations. These variations were not limited to SL class level only as the proportion of different molecular species containing variable number of carbons in fatty acid chains also differed between the isolates. Also a comparative analysis revealed abundance of ceramides and glu

SUBMITTER: Ali B 

PROVIDER: S-EPMC10941814 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature