Safety of fluconazole in kidney transplant recipients for prevention of coccidioidomycosis.

ABSTRACT: Coccidioides is an endemic fungus that causes infections ranging from mild respiratory illness to life-threatening disease, and immunocompromised hosts such as solid organ transplant recipients are at higher risk for disseminated infection and mortality. Our center administers fluconazole prophylaxis to kidney transplant recipients residing in geographic areas with higher incidences of coccidioidomycosis. However, because drug-drug interactions occur between triazoles and immunosuppressants used in transplant medicine, we undertook a study to ascertain whether fluconazole prophylaxis was associated with any important safety outcomes in kidney transplant recipients. This retrospective study evaluated patients who had undergone kidney transplantation between 2016 and 2019. Data on patient de

SUBMITTER: Reddy L 

PROVIDER: S-EPMC10941972 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature