The role of proteinaceous toxins secreted by <i>Staphylococcus aureus</i> in interbacterial competition.

ABSTRACT: Staphylococcus aureus is highly adapted to colonization of the mammalian host. In humans the primary site of colonization is the epithelium of the nasal cavity. A major barrier to colonization is the resident microbiota, which have mechanisms to exclude S. aureus. As such, S. aureus has evolved mechanisms to compete with other bacteria, one of which is through secretion of proteinaceous toxins. S. aureus strains collectively produce a number of well-characterized Class I, II, and IV bacteriocins as well as several bacteriocin-like substances, about which less is known. These bacteriocins have potent antibacterial activity against several Gram-positive organisms, with some also active against Gram-negative species. S. aureus bacteriocins characterized to d

SUBMITTER: Garrett SR 

PROVIDER: S-EPMC10941976 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature