Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment.

ABSTRACT: In a variety of neurons, action potentials (APs) initiate at the proximal axon, within a region called the axon initial segment (AIS), which has a high density of voltage-gated sodium channels (NaVs) on its membrane. In pyramidal neurons, the proximal AIS has been reported to exhibit a higher proportion of NaVs with gating properties that are "right-shifted" to more depolarized voltages, compared to the distal AIS. Further, recent experiments have revealed that as neurons develop, the spatial distribution of NaV subtypes along the AIS can change substantially, suggesting that neurons tune their excitability by modifying said distribution. When neurons are stimulated axonally, computational modelling has shown that this spatial separation of gating properties in the AIS enhances the backpro

SUBMITTER: Barlow BSM 

PROVIDER: S-EPMC10942053 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature