Circulating metabolic markers after surgery identify patients at risk for severe postoperative complications: a prospective cohort study in colorectal cancer.

ABSTRACT:

Background

Early detection of postoperative complications after colorectal cancer (CRC) surgery is associated with improved outcomes. The aim was to investigate early metabolomics signatures capable to detect patients at risk for severe postoperative complications after CRC surgery.

Materials and methods

Prospective cohort study of patients undergoing CRC surgery from 2015 to 2018. Plasma samples were collected before and after surgery, and analyzed by mass spectrometry obtaining 188 metabolites and 21 ratios. Postoperative complications were registered with Clavien-Dindo Classification and Comprehensive Complication Index.

Results

One hundred forty-six patients were included. Surgery substantially modified metabolome and metabolic changes after surgery were quantitat

SUBMITTER: Montcusi B 

PROVIDER: S-EPMC10942180 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature