Primary HIV infection features colonic damage and neutrophil inflammation yet containment of microbial translocation.

ABSTRACT:

Introduction

Impairment of the gastrointestinal barrier leads to microbial translocation and peripheral immune activation, which are linked to disease progression. Data in the setting of primary HIV/SIV infection suggest that gut barrier damage is one of the first events of the pathogenic cascade, preceding mucosal immune dysfunction and microbial translocation. We assessed gut structure and immunity as well as microbial translocation in acutely and chronically-infected, combination antiretroviral therapy (cART)-naive individuals.

Methods

Fifteen people with primary HIV infection (P-HIV) and 13 with chronic HIV infection (C-HIV) c-ART-naive participants were cross-sectionally studied. Gut biopsies were analysed in terms of gut reservoirs (total, integrated and unintegrated H

SUBMITTER: Tincati C 

PROVIDER: S-EPMC10942218 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature