Manifold learning uncovers nonlinear interactions between the adolescent brain and environment that predict emotional and behavioral problems.

ABSTRACT:

Background

To progress adolescent mental health research beyond our present achievements - a complex account of brain and environmental risk factors without understanding neurobiological embedding in the environment - we need methods to unveil relationships between the developing brain and real-world environmental experiences.

Methods

We investigated associations among brain function, environments, and emotional and behavioral problems using participants from the Adolescent Brain and Cognitive Development Study (N=2,401 female). We applied manifold learning, a promising technique for uncovering latent structure from high-dimensional biomedical data like functional magnetic resonance imaging (fMRI). Specifically, we developed exogenous PHATE (E-PHATE) to model brain-en

SUBMITTER: Busch EL 

PROVIDER: S-EPMC10942356 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature