Diffusion kurtosis MRI tracks gray matter myelin content in the primate cerebral cortex.

ABSTRACT: Diffusion magnetic resonance imaging (dMRI) has been widely employed to model the trajectory of myelinated fiber bundles in white matter. Increasingly, dMRI is also used to assess local tissue properties throughout the brain. In the cerebral cortex, myelin content is a critical indicator of the maturation, regional variation, and disease related degeneration of gray matter tissue. Gray matter myelination can be measured and mapped using several non-diffusion MRI strategies; however, first order diffusion statistics such as fractional anisotropy (FA) show only weak spatial correlation with cortical myelin content. Here we show that a simple higher order diffusion parameter, the mean diffusion kurtosis (MK), is strongly correlated with the laminar and regional variation of myelin in the prim

SUBMITTER: Reveley C 

PROVIDER: S-EPMC10942417 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature