Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution.

ABSTRACT: Species of the Bacteroidales order are among the most abundant and stable bacterial members of the human gut microbiome with diverse impacts on human health. While Bacteroidales strains and species are genomically and functionally diverse, order-wide comparative analyses are lacking. We cultured and sequenced the genomes of 408 Bacteroidales isolates from healthy human donors representing nine genera and 35 species and performed comparative genomic, gene-specific, mobile gene, and metabolomic analyses. Families, genera, and species could be grouped based on many distinctive features. However, we also show extensive DNA transfer between diverse families, allowing for shared traits and strain evolution. Inter- and intra-specific diversity is also apparent in the metabolomic profiling studies

SUBMITTER: Zhang ZJ 

PROVIDER: S-EPMC10942478 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature