Local Volume Concentration, Packing Domains and Scaling Properties of Chromatin.

ABSTRACT: We propose the Self Returning Excluded Volume (SR-EV) model for the structure of chromatin based on stochastic rules and physical interactions. The SR-EV rules of return generate conformationally-defined domains observed by single cell imaging techniques. From nucleosome to chromosome scales, the model captures the overall chromatin organization as a corrugated system, with dense and dilute regions alternating in a manner that resembles the mixing of two disordered bi-continuous phases. This particular organizational topology is a consequence of the multiplicity of interactions and processes occurring in the nuclei, and mimicked by the proposed return rules. Single configuration properties and ensemble averages show a robust agreement between theoretical and experimental results inc

SUBMITTER: Carignano M 

PROVIDER: S-EPMC10942481 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature