Thalamic stimulation induced changes in network connectivity and excitability in epilepsy.

ABSTRACT:

Background

The clinical effects of deep brain stimulation for neurological conditions manifest across multiple timescales, spanning seconds to months, and involve direct electrical modulation, neuroplasticity, and network reorganization. In epilepsy, the delayed effects of deep brain stimulation on seizures limit optimization. Single pulse electrical stimulation and the resulting pulse evoked potentials offer a measure network effective connectivity and excitability. This study leverages single pulse and high frequency thalamic stimulation during stereotactic electroencephalography to assess seizure network engagement, modulate network activity, and track changes in excitability and epileptiform abnormalities.

Methods

Ten individuals with drug resistant epilepsy undergoing c

SUBMITTER: Gregg NM 

PROVIDER: S-EPMC10942513 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature