A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle.

ABSTRACT: The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the 'Hernandez-Hernandez model', of electrical and Ca²⁺ signaling in arterial myocytes based on new experimental data indicating sex-specific differences in male and female arterial myocytes from murine resistance arteries. The model suggests the fundamental ionic mechanisms underlying membrane potential and intracellular Ca²⁺ signaling during the development of myogenic tone in arterial blood vessels. Although experimental data suggest that K_V1.5 channel currents have similar amplitudes, kinetics, and voltage dependencie

SUBMITTER: Hernandez-Hernandez G 

PROVIDER: S-EPMC10942543 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature