Tailoring T_fh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques.

ABSTRACT: CD4 T follicular helper cells (T_fh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into T_fh subsets that promote antibody persistence and functional capacity can critically inform vaccine design. Based on the T_fh profiles evoked by the live attenuated measles virus vaccine, renowned for its ability to establish durable humoral immunity, we investigated the potential of a T_fh1/17 recall response during the boost phase to enhance persistence of HIV-1 Envelope (Env) antibodies in rhesus macaques. Using a DNA-prime encoding gp160 antigen and T_fh polarizing cytokines (interferon protein-10 (IP-10) and interleukin-6 (IL-6)), fo

SUBMITTER: Verma A 

PROVIDER: S-EPMC10942585 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature