Gene-environment pathways to cognitive intelligence and psychotic-like experiences in children.

ABSTRACT: In children, psychotic-like experiences (PLEs) are related to risk of psychosis, schizophrenia, and other mental disorders. Maladaptive cognitive functioning, influenced by genetic and environmental factors, is hypothesized to mediate the relationship between these factors and childhood PLEs. Using large-scale longitudinal data, we tested the relationships of genetic and environmental factors (such as familial and neighborhood environment) with cognitive intelligence and their relationships with current and future PLEs in children. We leveraged large-scale multimodal data of 6,602 children from the Adolescent Brain and Cognitive Development Study. Linear mixed model and a novel structural equation modeling (SEM) method that allows estimation of both components and factors were used to esti

SUBMITTER: Park J 

PROVIDER: S-EPMC10942586 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature