Sequentially activated discrete modules appear as traveling waves in neuronal measurements with limited spatiotemporal sampling.

ABSTRACT: Numerous studies have identified traveling waves in the cortex and suggested they play important roles in brain processing. These waves are most often measured using macroscopic methods that are unable to assess the local spiking activity underlying wave dynamics. Here, we investigated the possibility that waves may not be traveling at the single neuron scale. We first show that sequentially activating two discrete brain areas can appear as traveling waves in EEG simulations. We next reproduce these results using an analytical model of two sequentially activated regions. Using this model, we were able to generate wave-like activity with variable directions, velocities, and spatial patterns, and to map the discriminability limits between traveling waves and modular sequential activations. F

SUBMITTER: Orsher Y 

PROVIDER: S-EPMC10942589 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature