A dynamical computational model of theta generation in hippocampal circuits to study theta-gamma oscillations during neurostimulation.

ABSTRACT: Neurostimulation of the hippocampal formation has shown promising results for modulating memory but the underlying mechanisms remain unclear. In particular, the effects on hippocampal theta-nested gamma oscillations and theta phase reset, which are both crucial for memory processes, are unknown. Moreover, these effects cannot be investigated using current computational models, which consider theta oscillations with a fixed amplitude and phase velocity. Here, we developed a novel computational model that includes the medial septum, represented as a set of abstract Kuramoto oscillators producing a dynamical theta rhythm with phase reset, and the hippocampal formation, composed of biophysically realistic neurons and able to generate theta-nested gamma oscillations under theta drive. We showed

SUBMITTER: Vardalakis N 

PROVIDER: S-EPMC10942594 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature