Parahippocampal neurons encode task-relevant information for goal-directed navigation.

ABSTRACT: A behavioral strategy crucial to survival is directed navigation to a goal, such as a food or home location. One potential neural substrate for supporting goal-directed navigation is the parahippocampus, which contains neurons that represent an animal's position, orientation, and movement through the world, and that change their firing activity to encode behaviorally relevant variables such as reward. However, little prior work on the parahippocampus has considered how neurons encode variables during goal-directed navigation in environments that dynamically change. Here, we recorded single units from rat parahippocampal cortex while subjects performed a goal-directed task. The maze dynamically changed goal-locations via a visual cue on a trial-to-trial basis, requiring subjects to use cue-

SUBMITTER: Gonzalez A 

PROVIDER: S-EPMC10942598 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature