Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats.

ABSTRACT: Extinction is a specific example of learning where a previously reinforced stimulus or response is no longer reinforced, and the previously learned behaviour is no longer necessary and must be modified. Current theories suggest extinction is not the erasure of the original learning but involves new learning that acts to suppress the original behaviour. Evidence for this can be found when the original behaviour recovers following the passage of time (spontaneous recovery) or reintroduction of the reinforcement (i.e. reinstatement). Recent studies have shown that pharmacological manipulation of noradrenaline (NA) or its receptors can influence appetitive extinction; however, the role and source of endogenous NA in these effects are unknown. Here, we examined the role of the locus coeruleus (

SUBMITTER: Lui S 

PROVIDER: S-EPMC10942613 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature