The intricate relationship of G-Quadruplexes and bacterial pathogenicity islands.

ABSTRACT: The dynamic interplay between guanine-quadruplex (G4) structures and pathogenicity islands (PAIs) represents a captivating area of research with implications for understanding the molecular mechanisms underlying pathogenicity. This study conducted a comprehensive analysis of a large-scale dataset from reported 89 pathogenic strains of bacteria to investigate the potential interactions between G4 structures and PAIs. G4 structures exhibited an uneven and non-random distribution within the PAIs and were consistently conserved within the same pathogenic strains. Additionally, this investigation identified positive correlations between the number and frequency of G4 structures and the GC content across different genomic features, including the genome, promoters, genes, tRNA, and rRNA regions,

SUBMITTER: Lyu B 

PROVIDER: S-EPMC10942614 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature