Acetylcholine modulates the precision of prediction error in the auditory cortex.

ABSTRACT: A fundamental property of sensory systems is their ability to detect novel stimuli in the ambient environment. The auditory brain contains neurons that decrease their response to repetitive sounds but increase their firing rate to novel or deviant stimuli; the difference between both responses is known as stimulus-specific adaptation or neuronal mismatch (nMM). Here, we tested the effect of microiontophoretic applications of ACh on the neuronal responses in the auditory cortex (AC) of anesthetized rats during an auditory oddball paradigm, including cascade controls. Results indicate that ACh modulates the nMM, affecting prediction error responses but not repetition suppression, and this effect is manifested predominantly in infragranular cortical layers. The differential effect of ACh on r

SUBMITTER: Perez-Gonzalez D 

PROVIDER: S-EPMC10942646 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature