Cognitive deficits and altered functional brain network organization in pediatric brain tumor patients.

ABSTRACT: Survivors of pediatric brain tumors experience significant cognitive deficits from their diagnosis and treatment. The exact mechanisms of cognitive injury are poorly understood, and validated predictors of long-term cognitive outcome are lacking. Resting state functional magnetic resonance imaging allows for the study of the spontaneous fluctuations in bulk neural activity, providing insight into brain organization and function. Here, we evaluated cognitive performance and functional network architecture in pediatric brain tumor patients. Forty-nine patients (7-18 years old) with a primary brain tumor diagnosis underwent resting state imaging during regularly scheduled clinical visits. All patients were tested with a battery of cognitive assessments. Extant data from 139 typically developi

SUBMITTER: Seitzman BA 

PROVIDER: S-EPMC10942739 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature