Electrophysiological alterations during action semantic processing in Parkinson's disease.

ABSTRACT: Assessments of action semantics consistently reveal markers of Parkinson's disease (PD). However, neurophysiological signatures of the domain remain under-examined in this population, especially under conditions that allow patients to process stimuli without stringent time constraints. Here we assessed event-related potentials and time-frequency modulations in healthy individuals (HPs) and PD patients during a delayed-response semantic judgment task involving related and unrelated action-picture pairs. Both groups had shorter response times for related than for unrelated trials, but they exhibited discrepant electrophysiological patterns. HPs presented significantly greater N400 amplitudes as well as theta enhancement and mu desynchronization for unrelated relative to related trials. Conve

SUBMITTER: Diaz Rivera MN 

PROVIDER: S-EPMC10942755 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature