Comparative neuroimaging of sex differences in human and mouse brain anatomy.

ABSTRACT: In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but the causes of such differences are hard to parse. While mouse models are useful for understanding the cellular and mechanistic bases of sex-specific brain development, there have been no attempts to formally compare human and mouse neuroanatomical sex differences to ascertain how well they translate. Addressing this question would shed critical light on the use of the mouse as a translational model for sex differences in the human brain and provide insights into the degree to which sex differences in brain volume are conserved across mammals. Here, we use structural magnetic resonance imaging to conduct the first comparative neuroimaging study of sex-specific neuroanatomy o

SUBMITTER: Guma E 

PROVIDER: S-EPMC10942785 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature