Effect of lower body negative pressure on cardiac and cerebral function in postural orthostatic tachycardia syndrome: A pilot MRI assessment.

ABSTRACT: Postural orthostatic tachycardia syndrome (POTS) is characterized by an excessive heart rate (HR) response upon standing and symptoms indicative of inadequate cerebral perfusion. We tested the hypothesis that during lower body negative pressure (LBNP), individuals with POTS would have larger decreases in cardiac and cerebrovascular function measured using magnetic resonance (MR) imaging. Eleven patients with POTS and 10 healthy controls were studied at rest and during 20 min of -25 mmHg LBNP. Biventricular volumes, stroke volume (SV), cardiac output (Qc), and HR were determined by cardiac MR. Cerebral oxygen uptake (VO₂ ) in the superior sagittal sinus was calculated from cerebral blood flow (CBF; MR phase contrast), venous O₂ saturation (SvO₂ ; susceptomet

SUBMITTER: Skow RJ 

PROVIDER: S-EPMC10942852 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature