A Model-Based ¹³C-Sucrose Breath Test Diagnostic for Gut Function Disorders Characterized by a Loss of Sucrase-Isomaltase Enzymatic Activity.

ABSTRACT:

Background

Environmental enteric dysfunction (EED) causes malnutrition in children in low-resource settings. Stable-isotope breath tests have been proposed as noninvasive tests of altered nutrient metabolism and absorption in EED, but uncertainty over interpreting the breath curves has limited their use. The activity of sucrose-isomaltase, the glucosidase enzyme responsible for sucrose hydrolysis, may be reduced in EED. We previously developed a mechanistic model describing the dynamics of the ¹³C-sucrose breath test (¹³C-SBT) as a function of underlying metabolic processes.

Objectives

This study aimed to determine which breath test curve dynamics are associated with sucrose hydrolysis and with the transport and metabolism of the fructose and glucose mo

SUBMITTER: Brouwer AF 

PROVIDER: S-EPMC10942859 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature