The impact of bias of underlying literature in guidelines on its recommendations: assessment of the German fluoride guideline.

ABSTRACT:

Purpose

The significance of the underlying literature in clinical guidelines can be weakened by the risk of bias, which could negatively affect the recommendations. Especially in controversial matters, such as fluoride use for caries prevention in children, biased results may be not reliable and lead to incorrect conclusions. This study was performed to detect bias in underlying literature of the German guideline for caries prevention using fluoride in children, where no consensus was reached between paediatricians and paediatric dentists.

Methods

Three tools used for risk of bias assessments of different study designs were RoB 2 for RCTs, ROBINS-I for non-randomized studies, and ROBIS for systematic reviews. For each study cited in the guideline two independent risk of bias

SUBMITTER: Al Masri A 

PROVIDER: S-EPMC10942900 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature