Metagenomic insights into the wastewater resistome before and after purification at large‑scale wastewater treatment plants in the Moscow city.

ABSTRACT: Wastewater treatment plants (WWTPs) are considered to be hotspots for the spread of antibiotic resistance genes (ARGs). We performed a metagenomic analysis of the raw wastewater, activated sludge and treated wastewater from two large WWTPs responsible for the treatment of urban wastewater in Moscow, Russia. In untreated wastewater, several hundred ARGs that could confer resistance to most commonly used classes of antibiotics were found. WWTPs employed a nitrification/denitrification or an anaerobic/anoxic/oxic process and enabled efficient removal of organic matter, nitrogen and phosphorus, as well as fecal microbiota. The resistome constituted about 0.05% of the whole metagenome, and after water treatment its share decreased by 3-4 times. The resistomes were dominated by ARGs encoding res

SUBMITTER: Begmatov S 

PROVIDER: S-EPMC10942971 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature