Stroke emboli from patients with atrial fibrillation enriched with neutrophil extracellular traps.

ABSTRACT:

Background

Recent literature has demonstrated remarkable heterogeneity in the composition of acute ischemic stroke (AIS) emboli, which may impact susceptibility to therapy.

Objectives

In this study, we explored differences in proteomic composition of retrieved embolic material from patients with stroke with and without atrial fibrillation (AF) (AF+ and AF-, respectively).

Methods

The full proteome of retrieved thromboembolic material from 24 patients with AIS was obtained by mass spectrometry. Known marker proteins were assigned groups representing broad classes of embolus components: red blood cells, platelets, neutrophils, eosinophils, histones, complement, and other clotting-associated proteins (eg, fibrinogen). Relative protein abundances were compared between AF+

SUBMITTER: Akkipeddi SMK 

PROVIDER: S-EPMC10943055 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature