Platelet RNA sequencing reveals profile of caffeic acid affecting hemostasis in mice.

ABSTRACT:

Background

Caffeic acid (CA) is a naturally occurring phenolic compound with diverse pharmacologic properties. CA plays a crucial role in hemostasis by increasing platelet count. However, the mechanism by which CA regulates platelets to promote hemostasis remains unclear.

Objectives

We aim to identify the potential target pathways and genes by which CA regulates platelets to promote hemostasis.

Methods

We performed RNA sequencing (RNA-seq) analysis of mouse platelet pools in both the CA-gavaged group and phosphate-buffered saline-gavaged group.

Results

The 12,934 expressed transcripts had been annotated after platelet RNA-seq. Compared with the phosphate-buffered saline group, 987 differentially expressed genes (DEGs) were identified, of which 466 were downregu

SUBMITTER: Deng J 

PROVIDER: S-EPMC10943058 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature