Lanthanide luminescence nanothermometer with working wavelength beyond 1500 nm for cerebrovascular temperature imaging in vivo.

ABSTRACT: Nanothermometers enable the detection of temperature changes at the microscopic scale, which is crucial for elucidating biological mechanisms and guiding treatment strategies. However, temperature monitoring of micron-scale structures in vivo using luminescent nanothermometers remains challenging, primarily due to the severe scattering effect of biological tissue that compromises the imaging resolution. Herein, a lanthanide luminescence nanothermometer with a working wavelength beyond 1500 nm is developed to achieve high-resolution temperature imaging in vivo. The energy transfer between lanthanide ions (Er³⁺ and Yb³⁺) and H₂O molecules, called the environment quenching assisted downshifting process, is utilized to establish temperature-sensitive emissions

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10943110 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature