Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy.

ABSTRACT: Diabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives maladaptive structural changes and functional damage to the vasculature. Attenuation of this pathological remodeling of blood vessels remains an unmet target owing to paucity of information on the metabolic signatures of this process. Ca²⁺/calmodulin-dependent kinase II (CaMKII) is expressed in the vasculature and is implicated in the control of blood vessels homeostasis. Recently, CaMKII has attracted a special attention in view of its chronic upregulated activity in diabetic tissues, yet its role in the diabetic vasculature remains under investigation.This review highlights the physiological and pathological actions of CaMKII in the diabetic vasculature, with focus on the control of the dial

SUBMITTER: Chacar S 

PROVIDER: S-EPMC10943158 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature