Global analysis of T-cell groups reveals immunological features and common antigen targets of digestive tract tumors.

ABSTRACT:

Background

T cells are key players in the tumor immune microenvironment (TIME), as they can recognize and eliminate cancer cells that express neoantigens derived from somatic mutations. However, the diversity and specificity of T-cell receptors (TCRs) that recognize neoantigens are largely unknown, due to the high variability of TCR sequences among individuals.

Methods

To address this challenge, we applied GLIPH2, a novel algorithm that groups TCRs based on their predicted antigen specificity and HLA restriction, to cluster the TCR repertoire of 1,702 patients with digestive tract cancer. The patients were divided into five groups based on whether they carried tumor-infiltrating or clonal-expanded TCRs and calculated their TCR diversity. The prognosis, tumor subtype, gene mu

SUBMITTER: Li X 

PROVIDER: S-EPMC10943170 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature