Diagnostic accuracy of inflammatory markers in adults with suspected central nervous system infections.

ABSTRACT:

Objectives

We aimed to determine diagnostic accuracy of inflammatory markers in plasma and cerebrospinal fluid (CSF) for the diagnosis of central nervous system (CNS) infections and specifically bacterial meningitis.

Methods

We analyzed 12 cytokines, chemokines, and acute phase reactants in CSF and plasma of 738 patients with suspected neurological infection included in a multicenter prospective cohort. We determined diagnostic accuracy for predicting any CNS infection and bacterial meningitis.

Results

We included 738 episodes between 2017 and 2022, split into a derivation (n = 450) and validation cohort (n = 288). Of these patients, 224 (30%) were diagnosed with CNS infection, of which 81 (11%) with bacterial meningitis, 107 (14%) with viral meningitis or encephaliti

SUBMITTER: Olie SE 

PROVIDER: S-EPMC10943182 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature