Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients.

ABSTRACT:

Background

Alopecia Areata (AA) is an acquired autoimmune form of non-scarring hair loss. Adiponectin and its gene polymorphism were related to many autoimmune disorders.

Objective

Assessment of adiponectin serum levels and adiponectin gene (ADIPOQ) (rs2241766) Single Nucleoid Polymorphism (SNP) in AA patients and correlating the results with the disease severity in those patients.

Methods

This study included 75 AA patients and 75 age and gender-matched healthy subjects (controls). The severity of Alopecia Tool (SALT) score assessment to evaluate AA severity was done. Adiponectin serum levels by ELISA and ADIPOQ (rs2241766) SNP using PCR were performed.

Results

Adiponectin serum levels were significantly lower in AA patients than controls (p = 0.001). ADIPOQ (r

SUBMITTER: Farag AGA 

PROVIDER: S-EPMC10943264 | biostudies-literature | 2024 Mar-Apr

REPOSITORIES: biostudies-literature