Novel metabolic biomarker for early detection and diagnosis to the patients with gastric cardia adenocarcinoma.

ABSTRACT:

Background

Gastric cardia adenocarcinoma (GCA) is classified as Siewert type II adenocarcinoma at the esophagogastric junction in Western countries. The majority of GCA patients do not exhibit early warning symptoms, leading to over 90% of diagnoses at an advanced stage, resulting in a grim prognosis, with less than a 20% 5-year survival rate.

Method

Metabolic features of 276 GCA and 588 healthy controls were characterized through a widely-targeted metabolomics by UPLC-MS/MS analysis. This study encompasses a joint pathway analysis utilizing identified metabolites, survival analysis in both early and advanced stages, as well as high and negative and low expression of HER2 immunohistochemistry staining. Machine learning techniques and Cox regression models were employed to co

SUBMITTER: Wei MX 

PROVIDER: S-EPMC10943274 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature