Notch signaling genes and CD8⁺ T-cell dynamics: Their contribution to immune-checkpoint inhibitor therapy in oral squamous cell carcinoma: A retrospective study.

ABSTRACT:

Background

Aberrant Notch signaling pathway has been related with the tumorigenesis in head and neck region, involving oral cavity. Here, we report the correlation between mutations in the Notch signaling pathway and CD8⁺ T-cell infiltration via PD-L1, which lead to enhanced antitumor immunity and may target for immune-checkpoint inhibitors (ICIs) therapy.

Methods

This retrospective study analyzed the results of immunohistochemical staining for PD-L1 and CD8⁺ T-cell infiltration in 10 patients and whole-exome sequencing (WES) was conducted on five of these patients to identify frequently mutated genes.

Results

Four of 10 patients were positive for PD-L1 and CD8⁺ T. By analyzing WES in three of these four patients, we notably identified

SUBMITTER: Ogi K 

PROVIDER: S-EPMC10943361 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature