Protective role of Bacillus Calmette-Guerin vaccine in Alzheimer's disease progression: A systematic review and meta-analysis.

ABSTRACT: Introduction: Alzheimer's disease (AD) represents a significant societal challenge, highlighting the need to explore effective prevention and treatment approaches. Recent literature has suggested that Bacillus Calmette-Guérin (BCG) vaccine may be a viable therapeutic option for immune disorders associated with AD due to its immunomodulatory properties and protection against various diseases.

Methods

This systematic review aimed to evaluate the association of BCG vaccine in the prevention of AD using six medical-scientific databases. A meta-analytical approach was undertaken to estimate the risk of AD incidence in patients with and without BCG vaccine exposure, followed by subgroup analyses. A risk of bias (RoB) assessment was performed using the Newcastle-Ottawa Scale (NOS).

Resu

SUBMITTER: Umar TP 

PROVIDER: S-EPMC10943379 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature