Adaptation of sequential action benefits from timing variability related to lateral basal ganglia circuitry.

ABSTRACT: Streamlined action sequences must remain flexible should stable contingencies in the environment change. By combining analyses of behavioral structure with a circuit-specific manipulation in mice, we report on a relationship between action timing variability and successful adaptation that relates to post-synaptic targets of primary motor cortical (M1) projections to dorsolateral striatum (DLS). In a two-lever instrumental task, mice formed successful action sequences by, first, establishing action scaffolds and, second, smoothly extending action duration to adapt to increased task requirements. Interruption of DLS neurons in M1 projection territories altered this process, evoking higher-rate actions that were more stereotyped in their timing, reducing opportunities for success. Based on ev

SUBMITTER: Ferguson LA 

PROVIDER: S-EPMC10943431 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature