Long-term overall survival of patients who undergo breast-conserving therapy or mastectomy for early operable HER2-Positive breast cancer after preoperative systemic therapy: an observational cohort study.

ABSTRACT:

Background

Understanding the survival outcomes associated with breast-conserving therapy (BCT) and mastectomy after preoperative systemic therapy (PST) enables clinicians to provide more personalized treatment recommendations. However, lack of firm survival benefit data limits the breast surgery choices of human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients who receive PST. We sought to determine whether BCT or mastectomy after PST for early operable HER2-positive breast cancer is associated with better long-term survival outcomes and determine the degree to which PST response affects this association.

Methods

In this observational cohort study, we compared the long-term survival outcomes of BCT and mastectomy after PST for HER2-positive breast ca

SUBMITTER: He X 

PROVIDER: S-EPMC10943473 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature