Structural and biochemical basis of FLS2-mediated signal activation and transduction in rice.

ABSTRACT: The receptor-like kinase FLAGELLIN-SENSITIVE 2 (FLS2) functions as a bacterial flagellin receptor localized on the cell membrane of plants. In Arabidopsis, the co-receptor BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1) cooperates with FLS2 to detect the flagellin epitope flg22, resulting in formation of a signaling complex that triggers plant defense responses. However, the co-receptor responsible for recognizing and signaling the flg22 epitope in rice remains to be determined, and the precise structural mechanism underlying FLS2-mediated signal activation and transduction has not been clarified. This study presents the structural characterization of a kinase-dead mutant of the intracellular kinase domain of OsFLS2 (OsFLS2-KD^D1013A) in complex with ATP or ADP, resolved at resolutions

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC10943584 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature