Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Chronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) is a risk factor in cardiovascular and neurodegenerative diseases and is also associated with sarcopenia and frailties. The objective of this study was to assess each cytokine: IL-6, TNF, and IL-1β separately in the elderly with comorbidities against controls without diseases according to the data published in the available literature.

Methods

The electronic bibliographic PubMed database was systematically searched to select all the relevant studies published up to July 2023. The total number of the subjects involved in the meta-analysis included patients w

SUBMITTER: Tylutka A 

PROVIDER: S-EPMC10943692 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature