NLRC4 methylation and its response to intravenous immunoglobulin therapy in Kawasaki disease: a case control study.

ABSTRACT:

Background

Kawasaki disease (KD) is a systemic vasculitis accompanied by many systemic physiological and biochemical changes. Elucidating its molecular mechanisms is crucial for diagnosing and developing effective treatments. NLR Family CARD Domain Containing 4 (NLRC4) encodes the key components of inflammasomes that function as pattern recognition receptors. The purpose of this study was to investigate the potential of NLRC4 methylation as a biomarker for KD.

Methods

In this study, pyrosequencing was utilized to analyze NLRC4 promoter methylation in blood samples from 44 children with initial complete KD and 51 matched healthy controls. Methylation at five CpG sites within the NLRC4 promoter region was evaluated.

Results

Compared to controls, NLRC4 methylation signif

SUBMITTER: Yu B 

PROVIDER: S-EPMC10943762 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature