Causal relationship between dietary salt intake and dementia risk: Mendelian randomization study.

ABSTRACT:

Objective

Observational research has indicated a potential link between dietary salt intake and susceptibility to dementia. However, it is important to note that these types of studies are prone to the issues of reverse causation and residual confounding. Therefore, we conducted a two-sample Mendelian randomization (MR) study to explore the causality.

Method

To explore the causal relationship between them, this Mendelian randomization (MR) study incorporated summary statistics of dietary salt intake and dementia. We estimated the causality between salt intake and the risk of overall dementia and various subtypes of dementia, including Alzheimer's disease (AD), Vascular dementia (VaD), and Lewy body dementia (LBD). The inverse variance-weighted (IVW) method was the major MR a

SUBMITTER: Shi K 

PROVIDER: S-EPMC10943813 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature