Development of rice bran-derived nanoparticles with excellent anti-cancer activity and their application for peritoneal dissemination.

ABSTRACT:

Background

Rice bran a by-product of the rice milling process is currently underutilized. Recent studies have shown that plant-derived nanoparticles (pdNPs) can be mass-produced at a low cost and exhibit biological and therapeutic activities. Rice bran contains various anti-cancer compounds, including γ-oryzanol and γ-tocotrienol, and rice bran-derived nanoparticles (rbNPs) can be employed as novel therapeutic agents for cancer treatment.

Results

Koshihikari rice bran was suspended in water, and the suspension was centrifuged and filtered through a 0.45-µm-pore size syringe filter. The filtrate was ultracentrifuged, and the precipitates were suspended to obtain rbNPs. The rbNPs were negatively charged exosome-like nanoparticles with an average diameter of approximately 130 n

SUBMITTER: Sasaki D 

PROVIDER: S-EPMC10943818 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature