Integrative multi-omics characterization reveals sex differences in glioblastoma.

ABSTRACT:

Background

Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with limited treatment modalities and poor prognosis. Recent studies have highlighted the importance of considering sex differences in cancer incidence, prognosis, molecular disparities, and treatment outcomes across various tumor types, including colorectal adenocarcinoma, lung adenocarcinoma, and GBM.

Methods

We performed comprehensive analyses of large-scale multi-omics data (genomic, transcriptomic, and proteomic data) from TCGA, GLASS, and CPTAC to investigate the genetic and molecular determinants that contribute to the unique clinical properties of male and female GBM patients.

Results

Our results revealed several key differences, including enrichments of MGMT promoter me

SUBMITTER: Jang B 

PROVIDER: S-EPMC10943869 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature