Sex Differences in the Relationship Between Schizophrenia and the Development of Cardiovascular Disease.

ABSTRACT:

Background

There are few data on sex differences in the association between schizophrenia and the development of cardiovascular disease (CVD). We sought to clarify the relationship of schizophrenia with the risk of developing CVDs and to explore the potential modification effect of sex differences.

Methods and results

We conducted a retrospective analysis using the JMDC Claims Database between 2005 and 2022. The study population included 4 124 508 individuals aged 18 to 75 years without a history of CVD or renal replacement therapy. The primary end point is defined as a composite end point that includes myocardial infarction, angina pectoris, stroke, heart failure, atrial fibrillation, and pulmonary thromboembolism. During a mean follow-up of 1288±1001 days, we observed 182 

SUBMITTER: Komuro J 

PROVIDER: S-EPMC10944025 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature