Proteomic Associations of Adverse Outcomes in Human Heart Failure.

ABSTRACT:

Background

Identifying novel molecular drivers of disease progression in heart failure (HF) is a high-priority goal that may provide new therapeutic targets to improve patient outcomes. The authors investigated the relationship between plasma proteins and adverse outcomes in HF and their putative causal role using Mendelian randomization.

Methods and results

The authors measured 4776 plasma proteins among 1964 participants with HF with a reduced left ventricular ejection fraction enrolled in PHFS (Penn Heart Failure Study). Assessed were the observational relationship between plasma proteins and (1) all-cause death or (2) death or HF-related hospital admission (DHFA). The authors replicated nominally significant associations in the Washington University HF registry (N=1080).

SUBMITTER: Dib MJ 

PROVIDER: S-EPMC10944037 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature