Causal Relationship Between Branched-Chain Amino Acids and Hypertension: A Mendelian Randomization Study.

ABSTRACT:

Background

This study aimed to investigate the causal relationships between branched-chain amino acids (BCAAs) and the risks of hypertension via meta-analysis and Mendelian randomization analysis.

Methods and results

A meta-analysis of 32 845 subjects was conducted to evaluate the relationships between BCAAs and hypertension. In Mendelian randomization analysis, independent single-nucleotide polymorphisms associated with BCAAs at the genome-wide significance level were selected as the instrumental variables. Meanwhile, the summary-level data for essential hypertension and secondary hypertension end points were obtained from the FinnGen study. As suggested by the meta-analysis results, elevated BCAA levels were associated with a higher risk of hypertension (isoleucine: summar

SUBMITTER: Cai S 

PROVIDER: S-EPMC10944042 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature