Schizophrenia and Types of Stroke: A Mendelian Randomization Study.

ABSTRACT:

Background

Previous studies suggest an association between schizophrenia and stroke, but no studies have investigated stroke subtypes. We examined potential causal associations between schizophrenia and a range of atherosclerotic, embolic, and hemorrhagic stroke outcomes.

Methods and results

Two-sample Mendelian randomization analyses were conducted. The summary-level data (restricted to European ancestry) were obtained for schizophrenia and stroke: ischemic stroke, large-artery stroke, small-vessel stroke, cardioembolic stroke, and intracerebral hemorrhage. The associations between schizophrenia and each outcome were analyzed by an inverse variance weighting method primarily and Mendelian randomization Egger, weighted median, and weighted mode subsequently. The presence of

SUBMITTER: Nakada S 

PROVIDER: S-EPMC10944050 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature