Transient resting-state salience-limbic co-activation patterns in functional neurological disorders.

ABSTRACT:

Background

Functional neurological disorders were historically regarded as the manifestation of a dynamic brain lesion which might be linked to trauma or stress, although this association has not yet been directly tested yet. Analysing large-scale brain network dynamics at rest in relation to stress biomarkers assessed by salivary cortisol and amylase could provide new insights into the pathophysiology of functional neurological symptoms.

Methods

Case-control resting-state functional magnetic resonance imaging study of 79 patients with mixed functional neurological disorders (i.e., functional movement disorders, functional seizures, persistent perceptual-postural dizziness) and 74 age- and sex-matched healthy controls. Using a two-step hierarchical data-driven neuroimaging a

SUBMITTER: Weber S 

PROVIDER: S-EPMC10944183 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature